DNA methylation imprinting errors in spermatogenic cells from maturation arrest azoospermic patients
نویسندگان
چکیده
منابع مشابه
Imprinting methylation errors in ART
There has been an increase in incidence reports of rare imprinting disorders associated with assisted reproductive technology (ART). ART, including in vitro fertilization and intracytoplasmic sperm injections, is an important treatment for infertile people of reproductive age and increasingly produces children. The identification of epigenetic changes at imprinted loci in ART infants has led to...
متن کاملCharacterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies.
BACKGROUND There is an increased incidence of rare imprinting disorders associated with assisted reproduction technologies (ARTs). The identification of epigenetic changes at imprinted loci in ART infants has led to the suggestion that the techniques themselves may predispose embryos to acquire imprinting errors and diseases. However, it is still unknown at what point(s) these imprinting errors...
متن کاملO-6: Maturation of Spermatogenic Cells in Artificial Seminiferous Tubules
Background This study aimed to investigate whether Artificial Seminiferous Tubules (AST) coated with testicular extra cellular matrix (ECM) support maturation of spermatogenic cells from immature testes. MaterialsAndMethods Medical grade tubes coated with testicular ECM were used. Testes from immature mice were loaded in the concentration of 10000- 20000/ml. Tubes were then immersed in germ cel...
متن کاملImprinting by DNA methylation: from transgenes to endogenous gene sequences.
A number of transgenes in the mouse show variation in methylation and expression phenotypes dependent on parental transmission. It appears that there exist at least two types of transgene imprinting; one is retained on an essentially homozygous background, while the other requires heterozygosity at some modifying loci in the genome and is observed as differences in phenotype in reciprocal cross...
متن کاملAllele-specific DNA methylation: beyond imprinting.
Allele-specific DNA methylation (ASM) and allele-specific gene expression (ASE) have long been studied in genomic imprinting and X chromosome inactivation. But these types of allelic asymmetries, along with allele-specific transcription factor binding (ASTF), have turned out to be far more pervasive-affecting many non-imprinted autosomal genes in normal human tissues. ASM, ASE and ASTF have now...
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ژورنال
عنوان ژورنال: Andrology
سال: 2017
ISSN: 2047-2919
DOI: 10.1111/andr.12329